The Significant Reduction or Complete Eradication of Subcutaneous and Metastatic Lesions in a Pheochromocytoma Mouse Model after Immunotherapy Using Mannan-BAM, TLR Ligands, and Anti-CD40

The Significant Reduction or Complete Eradication of Subcutaneous and Metastatic Lesions in a Pheochromocytoma Mouse Model after Immunotherapy Using Mannan-BAM, TLR Ligands, and Anti-CD40

Therapeutic options for metastatic pheochromocytoma/paraganglioma (PHEO/PGL) are limited. Here, we tested an immunotherapeutic approach based on intratumoral injections of mannan-BAM with toll-like receptor ligands into subcutaneous PHEO in a mouse model. This therapy elicited a strong innate immuni...

Full description

Bibliographic Details
Main Authors: Veronika Caisova, Liping Li, Garima Gupta, Ivana Jochmanova, Abhishek Jha, Ondrej Uher, Thanh-Truc Huynh, Markku Miettinen, Ying Pang, Luma Abunimer, Gang Niu, Xiaoyuan Chen, Hans Kumar Ghayee, David Taïeb, Zhengping Zhuang, Jan Zenka, Karel Pacak
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
pheochromocytoma
paraganglioma
metastatic
immunotherapy
innate immunity
adaptive immunity
toll-like receptor
pathogen-associated molecular patterns
neutrophil
T cell
Online Access:https://www.mdpi.com/2072-6694/11/5/654

Internet

https://www.mdpi.com/2072-6694/11/5/654

Similar Items