A Cyclic Pentamethinium Salt Induces Cancer Cell Cytotoxicity through Mitochondrial Disintegration and Metabolic Collapse

A Cyclic Pentamethinium Salt Induces Cancer Cell Cytotoxicity through Mitochondrial Disintegration and Metabolic Collapse

Cancer cells preferentially utilize glycolysis for ATP production even in aerobic conditions (the Warburg effect) and adapt mitochondrial processes to their specific needs. Recent studies indicate that altered mitochondrial activities in cancer represent an actionable target for therapy. We previous...

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Bibliographic Details
Main Authors: Radovan Krejcir, Lucie Krcova, Pavlina Zatloukalova, Tomas Briza, Philip J. Coates, Martin Sterba, Petr Muller, Jarmila Kralova, Pavel Martasek, Vladimir Kral, Borivoj Vojtesek
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
cancer therapy
glucose metabolism
mitochondria
autophagy
Online Access:https://www.mdpi.com/1422-0067/20/17/4208

Internet

https://www.mdpi.com/1422-0067/20/17/4208

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