Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

IntroductionLoss-of-function TLR7 variants have been recently reported in a small number of males to underlie strong predisposition to severe COVID-19. We aimed to determine the presence of these rare variants in young men with severe COVID-19.MethodsWe prospectively studied males between 18 and 50...

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Main Authors: Xavier Solanich, Gardenia Vargas-Parra, Caspar I. van der Made, Annet Simons, Janneke Schuurs-Hoeijmakers, Arnau Antolí, Jesús del Valle, Gemma Rocamora-Blanch, Fernando Setién, Manel Esteller, Simon V. van Reijmersdal, Antoni Riera-Mestre, Joan Sabater-Riera, Gabriel Capellá, Frank L. van de Veerdonk, Ben van der Hoven, Xavier Corbella, Alexander Hoischen, Conxi Lázaro
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
COVID-19
SARS-CoV-2
host genetics
TLR7
immunodeficiency
genetic screening
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.719115/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.719115/full

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