HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype.

HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype.

Autoimmune hepatitis (AIH) is a chronic progressive liver disease. AIH is composed predominantly of type 1 in Japanese populations. The genetic and environmental factors are associated with the pathogenesis of AIH. HLA-DRB1*03:01 and *04:01 are associated with type 1 AIH in European and *04:05 in Ja...

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Main Authors: Shomi Oka, Hiroshi Furukawa, Michio Yasunami, Aya Kawasaki, Hitomi Nakamura, Minoru Nakamura, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Satoru Hashimoto, Atsushi Naganuma, Noriaki Naeshiro, Kaname Yoshizawa, Haruhiro Yamashita, Keisuke Ario, Hajime Ohta, Hironori Sakai, Iwao Yabuuchi, Atsushi Takahashi, Kazumichi Abe, Hiroshi Yatsuhashi, Shigeto Tohma, Hiromasa Ohira, Naoyuki Tsuchiya, Kiyoshi Migita
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5663488?pdf=render

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http://europepmc.org/articles/PMC5663488?pdf=render

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