Validation of Plasmodium falciparum dUTPase as the target of 5′-tritylated deoxyuridine analogues with anti-malarial activity

Validation of Plasmodium falciparum dUTPase as the target of 5′-tritylated deoxyuridine analogues with anti-malarial activity

Abstract Background Malaria remains as a major global problem, being one of the infectious diseases that engender highest mortality across the world. Due to the appearance of resistance and the lack of an effective vaccine, the search of novel anti-malarials is required. Deoxyuridine 5′-triphosphate...

Full description

Bibliographic Details
Main Authors: Guiomar Pérez-Moreno, Paula Sánchez-Carrasco, Luis Miguel Ruiz-Pérez, Nils Gunnar Johansson, Sylke Müller, Beatriz Baragaña, Shahienaz Emma Hampton, Ian Hugh Gilbert, Marcel Kaiser, Sandipan Sarkar, Thiyagamurthy Pandurangan, Vijeesh Kumar, Dolores González-Pacanowska
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Malaria Journal
Subjects:
Plasmodium falciparum
Deoxyuridine 5′-triphosphate nucleotido-hydrolase
5′-tritylated deoxyuridine analogues
Mode of action
Online Access:https://doi.org/10.1186/s12936-019-3025-2

Internet

https://doi.org/10.1186/s12936-019-3025-2

Similar Items