Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1.

Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1.

The molecular mechanisms underlying chordoma pathogenesis are unknown. We therefore sought to identify novel mutations to better understand chordoma biology and to potentially identify therapeutic targets. Given the relatively high costs of whole genome sequencing, we performed a focused genetic ana...

Full description

Bibliographic Details
Main Authors: Edwin Choy, Laura E MacConaill, Gregory M Cote, Long P Le, Jacson K Shen, Gunnlaugur P Nielsen, Anthony J Iafrate, Levi A Garraway, Francis J Hornicek, Zhenfeng Duan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4077728?pdf=render

Internet

http://europepmc.org/articles/PMC4077728?pdf=render

Similar Items