Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

Abstract The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood brain barrier, posing a particular chall...

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Bibliographic Details
Main Authors: Cristina Cudalbu, Pierre Bady, Marta Lai, Lijing Xin, Olga Gusyatiner, Marie-France Hamou, Mario Lepore, Jean-Philippe Brouland, Roy T. Daniel, Andreas F. Hottinger, Monika E. Hegi
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Acta Neuropathologica Communications
Subjects:
Glioblastoma
Invasion
1H MRS at ultra-high fields (UHF)
Transcriptome
Patient-derived orthotopic xenografts (PDOX)
Tumor host interaction
Online Access:https://doi.org/10.1186/s40478-021-01232-4

Internet

https://doi.org/10.1186/s40478-021-01232-4

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