A study on blocking store-operated Ca2+ entry in pulmonary arterial smooth muscle cells with xyloketals from marine fungi

A study on blocking store-operated Ca2+ entry in pulmonary arterial smooth muscle cells with xyloketals from marine fungi

In this study, the effect of four xyloketals 1-4 on store-operated calcium entry (SOCE) was investigated in primary distal pulmonary arterial smooth muscle cells (PASMCs) isolated from mice. The results showed that xyloketal A (1), an unusual ketal with C-3 symmetry, exhibited strong SOCE blocking a...

Full description

Bibliographic Details
Main Authors: Zhou Jie-Bin, Sun Ying-Ying, Zheng Ying-Lin, Yu Chu-Qin, Lin Hua-Qing, Pang Ji-Yan
Format: Article
Language:English
Published: Sciendo 2017-12-01
Series:Acta Pharmaceutica
Subjects:
xyloketal a
store-operated calcium entry
molecular docking
il-8
parallel artificial membrane permeability assay
Online Access:https://doi.org/10.1515/acph-2017-0032

Internet

https://doi.org/10.1515/acph-2017-0032

Similar Items