Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 Infections

Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 Infections

The hall mark of human immunodeficiency virus (HIV) infection is a gradual loss of CD4+ T-cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity that leads ultimately to death. HIV infection in humans is caused by two related yet distinct viruses: HIV-1 and HIV-2. HI...

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Bibliographic Details
Main Authors: K. K. Vidya Vijayan, Krithika Priyadarshini Karthigeyan, Srikanth P. Tripathi, Luke Elizabeth Hanna
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
CD4+ T-cell
immune activation
pyroptosis
HIV-1
HIV-2
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00580/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00580/full

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