Potent Activity of Composite Cyclin Dependent Kinase Inhibition against Hepatocellular Carcinoma

Potent Activity of Composite Cyclin Dependent Kinase Inhibition against Hepatocellular Carcinoma

Alterations in cell cycle regulators are common in hepatocellular carcinoma (HCC). We tested the efficacy of composite inhibition of CDKs 1, 2, 5, and 9 through dinaciclib on HCC. In vitro, dinaciclib exhibited potent antiproliferative activities in HCC cell lines regardless of Rb or c-myc expressio...

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Bibliographic Details
Main Authors: Yu-Yun Shao, Yong-Shi Li, Hung-Wei Hsu, Hang Lin, Han-Yu Wang, Rita Robin Wo, Ann-Lii Cheng, Chih-Hung Hsu
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
cell cycle
cyclin-dependent kinase
dinaciclib
hepatocellular carcinoma
Online Access:https://www.mdpi.com/2072-6694/11/10/1433

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https://www.mdpi.com/2072-6694/11/10/1433

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