Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome <it>Fgfr2</it><sup>+<it>P253R </it></sup>mice

Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome <it>Fgfr2</it><sup>+<it>P253R </it></sup>mice

<p>Abstract</p> <p>Background</p> <p>Apert syndrome is characterized by craniosynostosis and limb abnormalities and is primarily caused by FGFR2 +/P253R and +/S252W mutations. The former mutation is present in approximately one third whereas the latter mutation is prese...

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Main Authors: Hill Cheryl A, Martinez-Abadias Neus, Peter Inga, Zhou Xueyan, Uhlhorn Victoria L, Sun Miao, Wang Yingli, Percival Christopher J, Richtsmeier Joan T, Huso David L, Jabs Ethylin
Format: Article
Language:English
Published: BMC 2010-02-01
Series:BMC Developmental Biology
Online Access:http://www.biomedcentral.com/1471-213X/10/22

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http://www.biomedcentral.com/1471-213X/10/22

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