Dualmarker: a flexible toolset for exploratory analysis of combinatorial dual biomarkers for clinical efficacy

Abstract Background An increasing number of clinical trials require biomarker-driven patient stratification, especially for revolutionary immune checkpoint blockade therapy. Due to the complicated interaction between a tumor and its microenvironment, single biomarkers, such as PDL1 protein level, tu...

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Bibliographic Details
Main Authors: Xiaopeng Ma, Ruiqi Huang, Xikun Wu, Pei Zhang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-021-04050-6