A Hybrid Framework for Simultaneous Process and Solvent Optimization of Continuous Anti-Solvent Crystallization with Distillation for Solvent Recycling

Anti-solvent crystallization is frequently applied in pharmaceutical processes for the separation and purification of intermediate compounds and active ingredients. The selection of optimal solvent types is important to improve the economic performance and sustainability of the process, but is chall...

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Bibliographic Details
Main Authors: Jiayuan Wang, Lingyu Zhu, Richard Lakerveld
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Processes
Subjects:
Online Access:https://www.mdpi.com/2227-9717/8/1/63