In vivo site-specific transfection of naked plasmid DNA and siRNAs in mice by using a tissue suction device.

In vivo site-specific transfection of naked plasmid DNA and siRNAs in mice by using a tissue suction device.

We have developed an in vivo transfection method for naked plasmid DNA (pDNA) and siRNA in mice by using a tissue suction device. The target tissue was suctioned by a device made of polydimethylsiloxane (PDMS) following the intravenous injection of naked pDNA or siRNA. Transfection of pDNA encoding...

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Bibliographic Details
Main Authors: Kazunori Shimizu, Shigeru Kawakami, Kouji Hayashi, Hideyuki Kinoshita, Koichiro Kuwahara, Kazuwa Nakao, Mitsuru Hashida, Satoshi Konishi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3402481?pdf=render

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http://europepmc.org/articles/PMC3402481?pdf=render

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