Multiparametric investigation of non functionalized-AGuIX nanoparticles in 3D human airway epithelium models demonstrates preferential targeting of tumor cells

Multiparametric investigation of non functionalized-AGuIX nanoparticles in 3D human airway epithelium models demonstrates preferential targeting of tumor cells

Abstract Liquid deposit mimicking surface aerosolization in the airway is a promising strategy for targeting bronchopulmonary tumors with reduced doses of nanoparticle (NPs). In mimicking and studying such delivery approaches, the use of human in vitro 3D culture models can bridge the gap between 2D...

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Bibliographic Details
Main Authors: Lucie Sancey, Odile Sabido, Zhiguo He, Fabien Rossetti, Alain Guignandon, Valérie Bin, Jean-Luc Coll, Michèle Cottier, François Lux, Olivier Tillement, Samuel Constant, Christophe Mas, Delphine Boudard
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Nanobiotechnology
Subjects:
AGuIX® nanoparticles
3D human healthy and tumor airway models
Nanoparticle’s toxicity
Nanoparticle’s uptake
Tumor targeting
Online Access:http://link.springer.com/article/10.1186/s12951-020-00683-6

Internet

http://link.springer.com/article/10.1186/s12951-020-00683-6

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