Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease

Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease

Dietary choline metabolites, such as trimethylamine N-oxide and betaine, have been associated with coronary artery disease (CAD). Here, Hartiala et al. identify two genetic loci for betaine levels on chromosomes 2q34 and 5q14.1 and find that the 2q34 locus was also associated with other pathway inte...

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Bibliographic Details
Main Authors: Jaana A. Hartiala, W. H. Wilson Tang, Zeneng Wang, Amanda L. Crow, Alexandre F. R. Stewart, Robert Roberts, Ruth McPherson, Jeanette Erdmann, Christina Willenborg, Stanley L. Hazen, Hooman Allayee
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10558

Internet

https://doi.org/10.1038/ncomms10558

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