Nanoparticle delivery of a tetravalent E protein subunit vaccine induces balanced, type-specific neutralizing antibodies to each dengue virus serotype.

Nanoparticle delivery of a tetravalent E protein subunit vaccine induces balanced, type-specific neutralizing antibodies to each dengue virus serotype.

Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic shock syndrome. Dengue vaccine development is challenging because of the need to induce protection against four antigenically distinct DENV serotypes. Recent studies indicate that tetravalent DENV vaccines must induce...

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Bibliographic Details
Main Authors: Stefan W Metz, Ashlie Thomas, Alex Brackbill, Yi Xianwen, Michele Stone, Katie Horvath, Michael J Miley, Chris Luft, Joseph M DeSimone, Shaomin Tian, Aravinda M de Silva
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-09-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC6171938?pdf=render

Internet

http://europepmc.org/articles/PMC6171938?pdf=render

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