TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg

TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg

Summary: CD4+ T lymphocytes are crucial for controlling a range of innate and adaptive immune effectors. For CD8+ cytotoxic T lymphocyte (CTL) responses, CD4+ T cells can function as helpers (TH) to amplify magnitude and functionality or as regulatory cells (Treg) capable of profound inhibition. It...

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Bibliographic Details
Main Authors: Joseph S. Dolina, Joey Lee, Ryan Q. Griswold, Lara Labarta-Bajo, Sumetha Kannan, Jason A. Greenbaum, Nawal Bahia El Idrissi, Margot J. Pont, Michael Croft, Stephen P. Schoenberger
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720300553

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http://www.sciencedirect.com/science/article/pii/S2211124720300553

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