High-fat diet impacts more changes in beta-cell compared to alpha-cell transcriptome.

Characterization of endocrine-cell functions and associated molecular signatures in diabetes is crucial to better understand why and by which mechanisms alpha and beta cells cause and perpetuate metabolic abnormalities. The now recognized role of glucagon in diabetes control is a major incentive to...

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Bibliographic Details
Main Authors: Rodolphe Dusaulcy, Sandra Handgraaf, Florian Visentin, Cedric Howald, Emmanouil T Dermitzakis, Jacques Philippe, Yvan Gosmain
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0213299