Solid lipid nanoparticles of irbesartan: preparation, characterization, optimization and pharmacokinetic studies

Solid lipid nanoparticles of irbesartan: preparation, characterization, optimization and pharmacokinetic studies

ABSTRACT Irbesartan is an antihypertensive with limited bioavailability and solid lipid nanoparticles (SLN) is one of the approaches to improve bioavailability. Solid lipid nanoparticles were prepared using glyceryl monostearate by solvent emulsification method followed by probe sonication. Irbesart...

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Bibliographic Details
Main Authors: Deepthi Soma, Zenab Attari, Meka Sreenivasa Reddy, Atmakuri Damodaram, Kunnatur Balasundara Gupta Koteshwara
Format: Article
Language:English
Published: Universidade de São Paulo 2017-04-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Irbesartan/pharmacokinetics
Irbesartan/preparation
Irbesartan/bioavailability
Glyceryl monostearate
Solid lipid nanoparticles/characterization
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100602&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100602&lng=en&tlng=en

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