Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas

Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas

Summary: Evidence regarding intraductal papillary neoplasm of the bile duct (IPNB) as a type of precancerous lesion of cholangiocarcinoma is limited. Moreover, a reproducible in vivo model is lacking, and IPNB pathogenesis remains unclear. Here, we use a doxycycline-inducible tetracycline (Tet)-on m...

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Main Authors: Hiroyuki Tomita, Kaori Tanaka, Akihiro Hirata, Hideshi Okada, Hisashi Imai, Yohei Shirakami, Kotaro Ohnishi, Shigeyuki Sugie, Hitomi Aoki, Yuichiro Hatano, Kei Noguchi, Tomohiro Kanayama, Ayumi Niwa, Natsuko Suzui, Tatsuhiko Miyazaki, Takuji Tanaka, Haruhiko Akiyama, Masahito Shimizu, Kazuhiro Yoshida, Akira Hara
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Cell Reports
Subjects:
fibroblast growth factor 10
intraductal papillary neoplasm of the bile duct
peribiliary gland
bile duct stem/progenitor cell
cholangiocarcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721000851

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http://www.sciencedirect.com/science/article/pii/S2211124721000851

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