Anti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bone.

Anti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bone.

Breast cancer often metastasizes to bone causing osteolytic bone resorption which releases active TGFβ. Because TGFβ favors progression of breast cancer metastasis to bone, we hypothesized that treatment using anti-TGFβ antibody may reduce tumor burden and rescue tumor-associated bone loss in metast...

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Bibliographic Details
Main Authors: Swati Biswas, Jeffry S Nyman, JoAnn Alvarez, Anwesa Chakrabarti, Austin Ayres, Julie Sterling, James Edwards, Tapasi Rana, Rachelle Johnson, Daniel S Perrien, Scott Lonning, Yu Shyr, Lynn M Matrisian, Gregory R Mundy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3214031?pdf=render

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http://europepmc.org/articles/PMC3214031?pdf=render

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