Silencing CircHIPK3 Sponges miR-93-5p to Inhibit the Activation of Rac1/PI3K/AKT Pathway and Improves Myocardial Infarction-Induced Cardiac Dysfunction

Silencing CircHIPK3 Sponges miR-93-5p to Inhibit the Activation of Rac1/PI3K/AKT Pathway and Improves Myocardial Infarction-Induced Cardiac Dysfunction

The ceRNA network involving circular RNAs (circRNAs) is essential in the cardiovascular system. We investigated the underlying ceRNA network involving circHIPK3 in myocardial infarction (MI). After an MI model was established, cardiac function was verified, and myocardial tissue damage in mice with...

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Bibliographic Details
Main Authors: Yijin Wu, Min Wu, Jue Yang, Ying Li, Wenying Peng, Meifen Wu, Changjiang Yu, Miaoxian Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
myocardial infarction
cardiac dysfunction
circHIPK3
miR-93-5p
Rac1
PI3K/AKT pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.645378/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.645378/full

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