Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.

HLA class-I alleles differ in their ability to control HIV replication through cell-mediated immune responses. No consistent associations have been found between the breadth of Cytotoxic T Lymphocytes (CTL) responses and the control of HIV-1, and it is unknown whether the size or distribution of the...

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Bibliographic Details
Main Authors: Morgane Rolland, David Heckerman, Wenjie Deng, Christine M Rousseau, Hoosen Coovadia, Karen Bishop, Philip J R Goulder, Bruce D Walker, Christian Brander, James I Mullins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2170517?pdf=render