Abiraterone acetate and prednisone in chemotherapy-naïve prostate cancer patients: rationale, evidence and clinical utility

Abiraterone acetate 1000 mg/day, combined with prednisone 5 mg PO twice daily, is indicated for the treatment of metastatic castration-resistant prostate cancer (mCRPC). Abiraterone acetate is the oral prodrug of abiraterone, a specific CYP17 inhibitor that blocks androgen biosynthesis within the ad...

Full description

Bibliographic Details
Main Authors: E. David Crawford, Neal D. Shore, Daniel P. Petrylak, Celestia S. Higano, Charles J. Ryan
Format: Article
Language:English
Published: SAGE Publishing 2017-05-01
Series:Therapeutic Advances in Medical Oncology
Online Access:https://doi.org/10.1177/1758834017698644