Novel GLP-1 Analog Supaglutide Stimulates Insulin Secretion in Mouse and Human Islet Beta-Cells and Improves Glucose Homeostasis in Diabetic Mice

Novel GLP-1 Analog Supaglutide Stimulates Insulin Secretion in Mouse and Human Islet Beta-Cells and Improves Glucose Homeostasis in Diabetic Mice

Glucagon-like peptide-1 (GLP-1), an incretin hormone plays an important role in regulating glucose homeostasis. The therapeutic use of native GLP-1 is inadequate due to its short in vivo half-life. We recently developed a novel GLP-1 mimetics supaglutide, and demonstrated that this formulation retai...

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Bibliographic Details
Main Authors: Liwei Ren, Qiaoli Cui, Wenjuan Liu, Liqian Wang, Yijing Liao, Ying Feng, Wanwan Sun, Yehong Yang, Zhaoyun Zhang, Tianru Jin, Gerald J. Prud’homme, Lina Zhang, Yiming Li, Ying Leng, Qinghua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Physiology
Subjects:
GLP-1
supaglutide
diabetes
insulin
glucose homeostasis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00930/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00930/full

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