Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease

Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease

Wolfram syndrome (WFS) is a progressive neurodegenerative disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. WFS1 and WFS2 are caused by recessive mutations in the genes Wolfram Syndrome 1 (WFS1) and CDGSH iron sulfur domain 2 (CISD2), respectively. To explo...

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Bibliographic Details
Main Authors: Melanie A. Jones, Sami Amr, Aerial Ferebee, Phung Huynh, Jill A. Rosenfeld, Michael F. Miles, Andrew G. Davies, Christopher A. Korey, John M. Warrick, Rita Shiang, Sarah H. Elsea, Santhosh Girirajan, Mike Grotewiel
Format: Article
Language:English
Published: The Company of Biologists 2014-04-01
Series:Biology Open
Subjects:
RNA interference
Neurodegeneration
Genetic modifiers
Wolfram syndrome
Copy number variants
Lysosomal storage disease
Gene network
Online Access:http://bio.biologists.org/content/3/5/342

Internet

http://bio.biologists.org/content/3/5/342

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