The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia

The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia

Summary: Liver-specific disruption of the type 2 deiodinase gene (Alb-D2KO) results in resistance to both diet-induced obesity and liver steatosis in mice. Here, we report that this is explained by an ∼60% reduction in liver zinc-finger protein-125 (Zfp125) expression. Zfp125 is a Foxo1-inducible tr...

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Bibliographic Details
Main Authors: Gustavo W. Fernandes, Barbara M.L.C. Bocco, Tatiana L. Fonseca, Elizabeth A. McAninch, Sungro Jo, Lattoya J. Lartey, InSug O-Sullivan, Terry G. Unterman, Nailliw Z. Preite, Robin M. Voigt, Christopher B. Forsyth, Ali Keshavarzian, Richárd Sinkó, Allison B. Goldfine, Mary E. Patti, Miriam O. Ribeiro, Balázs Gereben, Antonio C. Bianco
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717318776

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http://www.sciencedirect.com/science/article/pii/S2211124717318776

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