The Combination of CD8αα and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken γδT Cells Response

The Combination of CD8αα and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken γδT Cells Response

The CD8αα homodimer is crucial to both thymic T cell selection and the antigen recognition of cytotoxic T cells. The CD8-pMHC-I interaction can enhance CTL immunity via stabilizing the TCR-pMHC-I interaction and optimizing the cross-reactivity and Ag sensitivity of CD8+ T cells at various stages of...

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Bibliographic Details
Main Authors: Yanjie Liu, Rong Chen, Ruiying Liang, Beibei Sun, Yanan Wu, Lijie Zhang, Jim Kaufman, Chun Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
chicken γδT cells response
CD8/pMHC-I interaction
face-to-face mode
cCD8αα/pBF2*1501
cCD8αα/pBF2*0401
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.605085/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.605085/full

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