The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes

The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes

Abstract The α3* nAChRs, which are considered to be promising drug targets for problems such as pain, addiction, cardiovascular function, cognitive disorders etc., are found throughout the central and peripheral nervous system. The α-conotoxin (α-CTx) LvIA has been identified as the most selective i...

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Bibliographic Details
Main Authors: Manyu Xu, Xiaopeng Zhu, Jinfang Yu, Jinpeng Yu, Sulan Luo, Xinquan Wang
Format: Article
Language:English
Published: SpringerOpen 2017-06-01
Series:Protein & Cell
Subjects:
base editor
high-fidelity
mouse embryos
proximal-site deamination
whole-genome sequencing
Online Access:http://link.springer.com/article/10.1007/s13238-017-0426-2

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http://link.springer.com/article/10.1007/s13238-017-0426-2

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