Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

Summary: Generation of protective immunity to infections and vaccinations declines with age. Studies in healthy individuals have implicated reduced miR-181a expression in T cells as contributing to this defect. To understand the impact of miR-181a expression on antiviral responses, we examined LCMV...

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Bibliographic Details
Main Authors: Chulwoo Kim, Rohit R. Jadhav, Claire E. Gustafson, Megan J. Smithey, Alec J. Hirsch, Jennifer L. Uhrlaub, William H. Hildebrand, Janko Nikolich-Žugich, Cornelia M. Weyand, Jörg J. Goronzy
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719313580

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http://www.sciencedirect.com/science/article/pii/S2211124719313580

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