Prolonged infection triggered by dormant Mycobacterium tuberculosis: Immune and inflammatory responses in lungs of genetically susceptible and resistant mice.

Prolonged infection triggered by dormant Mycobacterium tuberculosis: Immune and inflammatory responses in lungs of genetically susceptible and resistant mice.

We developed an approach for substantial attenuation of Mycobacterium tuberculosis by prolonged culturing under gradually acidifying conditions. Bacteria subjected to acidification lost the capacity to form colonies on solid media, but readily resuscitated their growth in the murine host, providing...

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Bibliographic Details
Main Authors: Tatiana Kondratieva, Margarita Shleeva, Marina Kapina, Elvira Rubakova, Irina Linge, Alexander Dyatlov, Elena Kondratieva, Arseny Kaprelyants, Alexander Apt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0239668

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https://doi.org/10.1371/journal.pone.0239668

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