Impact of the NO-Sensitive Guanylyl Cyclase 1 and 2 on Renal Blood Flow and Systemic Blood Pressure in Mice

Impact of the NO-Sensitive Guanylyl Cyclase 1 and 2 on Renal Blood Flow and Systemic Blood Pressure in Mice

Nitric oxide (NO) modulates renal blood flow (RBF) and kidney function and is involved in blood pressure (BP) regulation predominantly via stimulation of the NO-sensitive guanylyl cyclase (NO-GC), existing in two isoforms, NO-GC1 and NO-GC2. Here, we used isoform-specific knockout (KO) mice and inve...

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Bibliographic Details
Main Authors: Evanthia Mergia, Manuel Thieme, Henning Hoch, Georgios Daniil, Lydia Hering, Mina Yakoub, Christina Rebecca Scherbaum, Lars Christian Rump, Doris Koesling, Johannes Stegbauer
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:International Journal of Molecular Sciences
Subjects:
renal blood flow
hypertension
NO-sensitive guanylyl cyclase
nitric oxide
cGMP
kidney
vasorelaxation
blood pressure
L-NAME
NO-GC
Online Access:http://www.mdpi.com/1422-0067/19/4/967

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http://www.mdpi.com/1422-0067/19/4/967

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