Cholesterol Stimulates the Transient Receptor Potential Melastatin 4 Channel in mpkCCDc14 Cells

Cholesterol Stimulates the Transient Receptor Potential Melastatin 4 Channel in mpkCCDc14 Cells

We have shown that cholesterol regulates the activity of ion channels in mouse cortical collecting duct (CCD) mpkCCDc14 cells and that the transient receptor potential melastatin 4 (TRPM4) channel is expressed in these cells. However, whether TRPM4 channel is regulated by cholesterol remains unclear...

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Bibliographic Details
Main Authors: Yong-Xu Cai, Bao-Long Zhang, Miao Yu, Yan-Chao Yang, Xue Ao, Di Zhu, Qiu-Shi Wang, Jie Lou, Chen Liang, Liang-Liang Tang, Ming-Ming Wu, Zhi-Ren Zhang, He-Ping Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
TRPM4
Cholesterol
PI(4,5)P2
Lipid rafts
Lovastatin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.627875/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.627875/full

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