Post-translational Modifications of the Peptidyl-Prolyl Isomerase Pin1

Post-translational Modifications of the Peptidyl-Prolyl Isomerase Pin1

The peptidyl-prolyl cis/trans isomerase (PPIase) Pin1 is a unique enzyme that only binds to Ser/Thr-Pro peptide motifs after phosphorylation and regulates the conformational changes of the bond. The Pin1-catalyzed isomerization upon phosphorylation can have profound effects on substrate biological f...

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Bibliographic Details
Main Authors: Dongmei Chen, Long Wang, Tae Ho Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Pin1
phosphorylation
oxidation
post-translational modification
SUMOylation
ubiquitination
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00129/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00129/full

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