EIF5A2 controls ovarian tumor growth and metastasis by promoting epithelial to mesenchymal transition via the TGFβ pathway

EIF5A2 controls ovarian tumor growth and metastasis by promoting epithelial to mesenchymal transition via the TGFβ pathway

Abstract Background Epithelial to mesenchymal transition (EMT) contributes to tumor metastasis and chemoresistance. Eukaryotic initiation factor 5A2 (EIF5A2) is highly expressed in a variety of human cancers but rarely expressed in normal tissues. While EIF5A2 has oncogenic activity in several cance...

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Bibliographic Details
Main Authors: Guannan Zhao, Wenjing Zhang, Peixin Dong, Hidemichi Watari, Yuqi Guo, Lawrence M. Pfeffer, Gabor Tigyi, Junming Yue
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cell & Bioscience
Subjects:
EIF5A2
CRISPR
Cas9 nickase
Lentiviral vector
Ovarian cancer
Epithelial to mesenchymal transition
Online Access:https://doi.org/10.1186/s13578-021-00578-5

Internet

https://doi.org/10.1186/s13578-021-00578-5

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