Proof-of-Concept Workflow for Establishing Reference Intervals of Human Urine Proteome for Monitoring Physiological and Pathological Changes

Proof-of-Concept Workflow for Establishing Reference Intervals of Human Urine Proteome for Monitoring Physiological and Pathological Changes

Urine as a true non-invasive sampling source holds great potential for biomarker discovery. While approximately 2000 proteins can be detected by mass spectrometry in urine from healthy people, the amount of these proteins vary considerably. A systematic evaluation of a large number of samples is nee...

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Bibliographic Details
Main Authors: Wenchuan Leng, Xiaotian Ni, Changqing Sun, Tianyuan Lu, Anna Malovannaya, Sung Yun Jung, Yin Huang, Yang Qiu, Guannan Sun, Matthew V. Holt, Chen Ding, Wei Sun, Xuebo Men, Tieliu Shi, Weimin Zhu, Yi Wang, Fuchu He, Bei Zhen, Guangshun Wang, Jun Qin
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:EBioMedicine
Subjects:
Reference intervals
Urine proteome
Cancer
Biomarker
Mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641730124X

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http://www.sciencedirect.com/science/article/pii/S235239641730124X

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