Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells

Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells

There is growing evidence that DNA repair factors have clinical value for cancer treatment. Nucleotide excision repair (NER) proteins, including excision repair cross-complementation group 2 (ERCC2), play a critical role in maintaining genome integrity. Here, we examined ERCC2 expression following e...

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Bibliographic Details
Main Authors: Sabeeta Kapoor, Trace Gustafson, Mutian Zhang, Ying-Shiuan Chen, Jia Li, Nhung Nguyen, Jorge Enrique Tovar Perez, Wan Mohaiza Dashwood, Praveen Rajendran, Roderick H. Dashwood
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
BET inhibition
colorectal cancer
DNA repair
epigenetic
HDAC inhibition
JQ1
Online Access:https://www.mdpi.com/2072-6694/13/6/1438

Internet

https://www.mdpi.com/2072-6694/13/6/1438

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