An engineered yeast efficiently secreting penicillin.

This study aimed at developing an alternative host for the production of penicillin (PEN). As yet, the industrial production of this beta-lactam antibiotic is confined to the filamentous fungus Penicillium chrysogenum. As such, the yeast Hansenula polymorpha, a recognized producer of pharmaceuticals...

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Bibliographic Details
Main Authors: Loknath Gidijala, Jan A K W Kiel, Rutger D Douma, Reza M Seifar, Walter M van Gulik, Roel A L Bovenberg, Marten Veenhuis, Ida J van der Klei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2789386?pdf=render