Reduced VGLUT2 expression increases motor neuron viability in Sod1G93A mice

Reduced VGLUT2 expression increases motor neuron viability in Sod1G93A mice

Glutamate-induced excitotoxicity has been suggested to influence pathogenesis in amyotrophic lateral sclerosis (ALS). Vesicular glutamate transporters (VGLUTs) are responsible for transport of glutamate into synaptic vesicles. Nerve terminals that envelop motor neurons in the spinal cord contain VGL...

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Bibliographic Details
Main Authors: Hanna Wootz, Anders Enjin, Åsa Wallén-Mackenzie, Dan Lindholm, Klas Kullander
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Neurobiology of Disease
Subjects:
ALS
Amyotrophic lateral sclerosis
Glutamate
Vglut2
Vesicular glutamate transporters
Excitotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002472

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http://www.sciencedirect.com/science/article/pii/S0969996109002472

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