PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

Processing the value of reward is thought to involve the rostromedial caudate (rmCD), but a causal demonstration is lacking in primates. Here the authors use chemogenetics and PET imaging to show that inactivation of rmCD leads to impairments in reward value judgments.

Bibliographic Details
Main Authors: Yuji Nagai, Erika Kikuchi, Walter Lerchner, Ken-ichi Inoue, Bin Ji, Mark A. G. Eldridge, Hiroyuki Kaneko, Yasuyuki Kimura, Arata Oh-Nishi, Yukiko Hori, Yoko Kato, Toshiyuki Hirabayashi, Atsushi Fujimoto, Katsushi Kumata, Ming-Rong Zhang, Ichio Aoki, Tetsuya Suhara, Makoto Higuchi, Masahiko Takada, Barry J. Richmond, Takafumi Minamimoto
Format: Article
Language:English
Published: Nature Publishing Group 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13605

Internet

https://doi.org/10.1038/ncomms13605

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