Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial

Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial

Abstract Background Leflunomide (LEF) is a first-line disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis (RA). However, there are still a few nonresponders. It is logical to suggest that employing combinations including LEF that produce synergistic effects in terms of pharmacologi...

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Bibliographic Details
Main Authors: Chi Zhang, Daogang Guan, Miao Jiang, Chao Liang, Li Li, Ning Zhao, Qinglin Zha, Wandong Zhang, Cheng Lu, Ge Zhang, Jian Liu, Aiping Lu
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Chinese Medicine
Subjects:
Rheumatoid arthritis
Leflunomide
Ligustrazine
Online Access:http://link.springer.com/article/10.1186/s13020-019-0247-8

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http://link.springer.com/article/10.1186/s13020-019-0247-8

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