Clinical Implications of Promoter Hypermethylation in RASSF1A and MGMT in Retinoblastoma

Clinical Implications of Promoter Hypermethylation in RASSF1A and MGMT in Retinoblastoma

We investigated the epigenetic silencing and genetic changes of the RAS-associated domain family 1A (RASSF1A) gene and the Os-methylguanine-DNA methyltransferase (MGMT) gene in retinoblastoma. We extracted DNA from microdissected tumor and normal retina tissues of the same patient in 68 retinoblast...

Full description

Bibliographic Details
Main Authors: Kwong Wai Choy, Tom C. Lee, Kin Fai Cheung, Dorothy S.P. Fan, Kwok Wai Lo, Katherine L. Beaverson, David H. Abramson, Dennis S.C. Lam, Christopher B.O. Yu, Chi Pui Pang
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Retinoblastoma
methylation
RASSF1A
MGMT
RB
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800211

Internet

http://www.sciencedirect.com/science/article/pii/S1476558605800211

Similar Items