Helicobacter pylori CagA Protein Negatively Regulates Autophagy and Promotes Inflammatory Response via c-Met-PI3K/Akt-mTOR Signaling Pathway

Helicobacter pylori CagA Protein Negatively Regulates Autophagy and Promotes Inflammatory Response via c-Met-PI3K/Akt-mTOR Signaling Pathway

Cytotoxin-associated-gene A (CagA) of Helicobacter pylori (H. pylori) is a virulence factor that plays critical roles in H. pylori-induced gastric inflammation. In the present study, gastric biopsies were used for genotyping cagA and vacA genes, determining the autophagic activity, and the severity...

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Bibliographic Details
Main Authors: Na Li, Bin Tang, Yin-ping Jia, Pan Zhu, Yuan Zhuang, Yao Fang, Qian Li, Kun Wang, Wei-jun Zhang, Gang Guo, Tong-jian Wang, You-jun Feng, Bin Qiao, Xu-hu Mao, Quan-ming Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Helicobacter pylori
autophagy
CagA
c-Met
SQSTM1
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00417/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00417/full

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