The toll-like receptor agonist imiquimod is active against prions.

The toll-like receptor agonist imiquimod is active against prions.

Using a yeast-based assay, a previously unsuspected antiprion activity was found for imiquimod (IQ), a potent Toll-like receptor 7 (TLR7) agonist already used for clinical applications. The antiprion activity of IQ was first detected against yeast prions [PSI (+) ] and [URE3], and then against mamma...

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Bibliographic Details
Main Authors: Nassima Oumata, Phu Hai Nguyen, Vincent Beringue, Flavie Soubigou, Yanhong Pang, Nathalie Desban, Catherine Massacrier, Yannis Morel, Carine Paturel, Marie-Astrid Contesse, Serge Bouaziz, Suparna Sanyal, Hervé Galons, Marc Blondel, Cécile Voisset
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3745460?pdf=render

Internet

http://europepmc.org/articles/PMC3745460?pdf=render

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