BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors
BRCA2 plays important roles in cell physiology by promoting DNA replication and DNA double-strand breaks repair. Here the authors, reveal the impact of BRCA2 depletion on the cell transcriptional program with activation of the innate immune response that is potentiated by PARP inhibitor treatments.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11048-5 |
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doaj-a4c12a795f2a4463a4d0d639093cc8682021-05-11T11:37:52ZengNature Publishing GroupNature Communications2041-17232019-07-0110111310.1038/s41467-019-11048-5BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitorsTimo Reisländer0Emilia Puig Lombardi1Florian J. Groelly2Ana Miar3Manuela Porru4Serena Di Vito5Benjamin Wright6Helen Lockstone7Annamaria Biroccio8Adrian Harris9Arturo Londoño-Vallejo10Madalena Tarsounas11Genome Stability and Tumourigenesis Group, The CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordInstitut Curie, PSL Research University, CNRS, UMR3244Genome Stability and Tumourigenesis Group, The CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordHypoxia and Angiogenesis Group, Weatherall Institute of Molecular Medicine, Department of Oncology, University of OxfordArea of Translational Research, IRCCS Regina Elena National Cancer InstituteArea of Translational Research, IRCCS Regina Elena National Cancer InstituteBioinformatics and Statistical Genetics Core, Wellcome Trust Centre for Human Genetics, University of OxfordBioinformatics and Statistical Genetics Core, Wellcome Trust Centre for Human Genetics, University of OxfordArea of Translational Research, IRCCS Regina Elena National Cancer InstituteHypoxia and Angiogenesis Group, Weatherall Institute of Molecular Medicine, Department of Oncology, University of OxfordInstitut Curie, PSL Research University, CNRS, UMR3244Genome Stability and Tumourigenesis Group, The CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordBRCA2 plays important roles in cell physiology by promoting DNA replication and DNA double-strand breaks repair. Here the authors, reveal the impact of BRCA2 depletion on the cell transcriptional program with activation of the innate immune response that is potentiated by PARP inhibitor treatments.https://doi.org/10.1038/s41467-019-11048-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Timo Reisländer Emilia Puig Lombardi Florian J. Groelly Ana Miar Manuela Porru Serena Di Vito Benjamin Wright Helen Lockstone Annamaria Biroccio Adrian Harris Arturo Londoño-Vallejo Madalena Tarsounas |
| spellingShingle |
Timo Reisländer Emilia Puig Lombardi Florian J. Groelly Ana Miar Manuela Porru Serena Di Vito Benjamin Wright Helen Lockstone Annamaria Biroccio Adrian Harris Arturo Londoño-Vallejo Madalena Tarsounas BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors Nature Communications |
| author_facet |
Timo Reisländer Emilia Puig Lombardi Florian J. Groelly Ana Miar Manuela Porru Serena Di Vito Benjamin Wright Helen Lockstone Annamaria Biroccio Adrian Harris Arturo Londoño-Vallejo Madalena Tarsounas |
| author_sort |
Timo Reisländer |
| title |
BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors |
| title_short |
BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors |
| title_full |
BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors |
| title_fullStr |
BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors |
| title_full_unstemmed |
BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors |
| title_sort |
brca2 abrogation triggers innate immune responses potentiated by treatment with parp inhibitors |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-07-01 |
| description |
BRCA2 plays important roles in cell physiology by promoting DNA replication and DNA double-strand breaks repair. Here the authors, reveal the impact of BRCA2 depletion on the cell transcriptional program with activation of the innate immune response that is potentiated by PARP inhibitor treatments. |
| url |
https://doi.org/10.1038/s41467-019-11048-5 |
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