Bone marrow stromal cells derived MCP-1 reverses the inhibitory effects of multiple myeloma cells on osteoclastogenesis by upregulating the RANK expression.

Bone marrow stromal cells derived MCP-1 reverses the inhibitory effects of multiple myeloma cells on osteoclastogenesis by upregulating the RANK expression.

Multiple myeloma (MM) cells are responsible for aberrant osteoclast (OC) activation. However, when cocultured monocytes, but not OC precursors, with MM cells, we made a novel observation that MM cells inhibited receptor activator of nuclear factor κB ligand (RANKL)-induced increase of OC differentia...

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Bibliographic Details
Main Authors: Zhiqiang Liu, Jingda Xu, Haiyan Li, Yuhuan Zheng, Jin He, Huan Liu, Yuping Zhong, Yong Lu, Bangxing Hong, Mingjun Zhang, Pei Lin, Juan Du, Jian Hou, Jianfei Qian, Larry W Kwak, Qing Yi, Jing Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3858321?pdf=render

Internet

http://europepmc.org/articles/PMC3858321?pdf=render

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