CD4 Depletion or CD40L Blockade Results in Antigen-Specific Tolerance in a Red Blood Cell Alloimmunization Model

CD4 Depletion or CD40L Blockade Results in Antigen-Specific Tolerance in a Red Blood Cell Alloimmunization Model

Approximately 3–10% of human red blood cell (RBC) transfusion recipients form alloantibodies to non-self, non-ABO blood group antigens expressed on donor RBCs, with these alloantibodies having the potential to be clinically significant in transfusion and pregnancy settings. However, the majority of...

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Bibliographic Details
Main Authors: Prabitha Natarajan, Dong Liu, Seema R. Patel, Manjula Santhanakrishnan, Daniel Beitler, Jingchun Liu, David R. Gibb, Justine S. Liepkalns, David J. Madrid, Stephanie C. Eisenbarth, Sean R. Stowell, Jeanne E. Hendrickson
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
red blood cell
alloimmunization
tolerance
CD40L blockade
T-cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00907/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00907/full

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