New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can potentially improve therapeutic response to many chemotherapeutic regimes. A new set of usnic acid derivatives with hydrazonothiazole pharmaco...

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Bibliographic Details
Main Authors: Aleksander S. Filimonov, Arina A. Chepanova, Olga A. Luzina, Alexandra L. Zakharenko, Olga D. Zakharova, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Maxim S. Kuprushkin, Anton V. Kolotaev, Derenik S. Khachatryan, Jinal Patel, Ivanhoe K.H. Leung, Raina Chand, Daniel M. Ayine-Tora, Johannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
tyrosyl-dna phosphodiesterase 1 (tdp1)
topotecan
topoisomerase 1
usnic acid
molecular modeling
synergetic effect
inhibiting activity
Online Access:https://www.mdpi.com/1420-3049/24/20/3711

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https://www.mdpi.com/1420-3049/24/20/3711

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