Germline Profiling and Molecular Characterization of Early Onset Metastatic Colorectal Cancer

Germline Profiling and Molecular Characterization of Early Onset Metastatic Colorectal Cancer

BackgroundEarly onset colorectal cancer (EO CRC) is a heterogeneous colorectal cancer subtype with obvious hereditary tendencies and increasing incidence. We sought to determine the susceptibility genes and molecular characteristics of EO CRC.Methods330 EO metastatic CRC (mCRC) (≤55 years) and 110 a...

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Bibliographic Details
Main Authors: Ting Xu, Yinjie Zhang, Jing Zhang, Changsong Qi, Dan Liu, Zhenghang Wang, Yanyan Li, Congcong Ji, Jian Li, Xuan Lin, Ting Hou, Hao Liu, Lu Zhang, Han Han-Zhang, Lin Shen, Xicheng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
early onset colorectal cancer
susceptibility gene
genomic alternation
prognosis
next generation sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.568911/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.568911/full

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